Numerical simulation of blood flow in 7 mitral valve replacement patients

Modelling datasets are based on CT and echo images of patients. Computer simulations are performed using an in-house finite-element software (CHeart) in different configurations for each patient to simulate the blood flow changes induced by implantation of an artificial mitral valve. More specifically, the aim of this study is to investigate the effects on ventricular hemodynamics that a partial occlusion of the left ventricular outflow tract can cause as a result of the implantation of a prosthetic valve. Related publication: de Vecchi et al. 2018. "Left ventricular outflow obstruction predicts increase in systolic pressure gradients and blood residence time after transcatheter mitral valve replacement" Nature Scientific Reports. Accepted.