MP
Maddy Parsons
Professor of Cell Biology (Biological sciences; Biomedical and clinical sciences; Health sciences)
London
Publications
- Slac2-b Coordinates Extracellular Vesicle Secretion to Regulate Keratinocyte Adhesion and Migration
- Spatial activation of ezrin by epidermal growth factor receptor and focal adhesion kinase co-ordinates epithelial cell migration
- Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth
- Nox4 regulates InsP3 receptor‐dependent Ca2+ release into mitochondria to promote cell survival
- Quantitative real-time imaging of intracellular FRET biosensor dynamics using rapid multi-beam confocal FLIM
- Golgi anti-apoptotic protein: a tale of camels, calcium, channels and cancer
- KIF22 coordinates CAR and EGFR dynamics to promote cancer cell proliferation
- Mena regulates the LINC complex to control actin–nuclear lamina associations, trans-nuclear membrane signalling and cancer gene expression
- Sequential binding of Ezrin and Moesin to L-selectin regulates monocyte protrusive behaviour during transmigration
- New perspectives on integrin-dependent adhesions
- Stimulation of cell invasion by the Golgi Ion Channel GAAP/TMBIM4 via an H2O2-Dependent Mechanism
- L-selectin regulates human neutrophil transendothelial migration.
- Aquaporins differentially regulate cell-cell adhesion in MDCK cells.
- Targeted fluorescence lifetime probes reveal responsive organelle viscosity and membrane fluidity.
- Microfluidic Devices for Examining the Physical Limits of Migration in Confined Environments.
- The manganese(III) porphyrin MnTnHex-2-PyP5+ modulates intracellular ROS and breast cancer cell migration: Impact on doxorubicin-treated cells
- Transmigration of leukocytes across epithelial monolayers
- FMNL2 regulates dynamics of fascin in filopodia
- TNFR1 membrane reorganization promotes distinct modes of TNFα signaling
- Deep sequencing of HIV-1 reverse transcripts reveals the multifaceted antiviral functions of APOBEC3G
- The β3-integrin endothelial adhesome regulates microtubule-dependent cell migration
- Two-Color, Two-Photon Imaging at Long Excitation Wavelengths Using a Diamond Raman Laser
- A small-molecule activator of kinesin-1 drives remodeling of the microtubule network
- NDP52 activates nuclear myosin VI to enhance RNA polymerase II transcription
- CAR: A key regulator of adhesion and inflammation
- Regulation of cell migration by α4 and α9 integrins
- In vivo topology converts competition for cell-matrix adhesion into directional migration
- Imaging of Human Cancer Cells in 3D Collagen Matrices
- Loss of Cannabinoid CB1 Receptors Induces Cortical Migration Malformations and Increases Seizure Susceptibility
- REMBI
- Redistribution of Adhesive Forces through Src/FAK Drives Contact Inhibition of Locomotion in Neural Crest
- A femtosecond Raman generator for long wavelength two-photon and third harmonic generation imaging
- Coagulation Factor XIII-A Subunit Missense Mutation in the Pathobiology of Autosomal Dominant Multiple Dermatofibromas
- Osimertinib and anti-HER3 combination therapy engages immune dependent tumor toxicity via STING activation in trans
- Metabolic perturbations in fibrotic disease
- CAR co-operates with integrins to promote lung cancer cell adhesion and invasion
- Homozygous acceptor splice site mutation in DSG1 disrupts plakoglobin localization and results in keratoderma and skin fragility
- Kindlin-1 regulates epidermal growth factor receptor signalling
- The Na+/H+ exchanger NHE1 localizes as clusters to cryptic lamellipodia and accelerates collective epithelial cell migration
- Fluorescence lifetime imaging for viscosity and diffusion measurements
- α2β1 integrins spatially restrict Cdc42 activity to stabilise adherens junctions
- Live imaging of ERK signalling dynamics in differentiating mouse embryonic stem cells
- Sub-diffraction error mapping for localisation microscopy images
- Dosage-dependent regulation of VAV2 expression by steroidogenic factor-1 drives adrenocortical carcinoma cell invasion
- Control of nuclear organization by F-actin binding proteins
- Local dimensionality determines imaging speed in localization microscopy
- Large Intragenic Deletion in DSTYK Underlies Autosomal-Recessive Complicated Spastic Paraparesis, SPG23
- Tumor angiogenesis is differentially regulated by phosphorylation of endothelial cell focal adhesion kinase tyrosines-397 and -861
- Semidominant GPNMB Mutations in Amyloidosis Cutis Dyschromica
- Fluorescence Recovery After Photobleaching (FRAP) with simultaneous Fluorescence Lifetime and time-resolved Fluorescence Anisotropy Imaging (FLIM & tr-FAIM)
- Using FRET to analyse signals controlling cell adhesion and migration
- PAK4 suppresses PDZ-RhoGEF activity to drive invadopodia maturation in melanoma cells
- Par3 controls neural crest migration by promoting microtubule catastrophe during contact inhibition of locomotion
- CAR regulates epithelial cell junction stability through control of E-cadherin trafficking
- Podoplanin mediates ECM degradation by squamous carcinoma cells through control of invadopodia stability
- Targeted redox inhibition of protein phosphatase 1 by Nox4 regulates eIF2α-mediated stress signaling
- Integrin α3β1-CD151 complex regulates dimerization of ErbB2 via RhoA
- Corrigendum to: Endothelial FAK is required for tumour angiogenesis (EMBO Mol Med, (2010), 2, (516-528), 10.1002/emmm.201000106)
- The light chains of kinesin-1 are autoinhibited
- hGAAP promotes cell adhesion and migration via the stimulation of store-operated Ca2+ entry and calpain 2.
- BPAG1-e Restricts Keratinocyte Migration Through Control of Adhesion Stability.
- Fascin regulates the migration of subventricular zone-derived neuroblasts in the postnatal brain.
- Phosphorylation of the Actin Binding Protein Drebrin at S647 Is Regulated by Neuronal Activity and PTEN.
- FAK-heterozygous mice display enhanced tumour angiogenesis.
- Integrin-Specific Control of Focal Adhesion Kinase and RhoA Regulates Membrane Protrusion and Invasion.
- Stromal Claudin14-heterozygosity, but not deletion, increases tumour blood leakage without affecting tumour growth.
- Germline Mutation in EXPH5 Implicates the Rab27B Effector Protein Slac2-b in Inherited Skin Fragility.
- The first World Cell Race.
- Fascin promotes filopodia formation independent of its role in actin bundling.
- Revertant mosaicism in Kindler syndrome.
- Autosomal recessive epidermolysis bullosa simplex due to loss of BPAG1-e expression.
- The transcription factor Erg regulates expression of histone deacetylase 6 and multiple pathways involved in endothelial cell migration and angiogenesis.
- Kindlin binds migfilin tandem LIM domains and regulates migfilin focal adhesion localization and recruitment dynamics.
- Cadherin Switch during EMT in Neural Crest Cells Leads to Contact Inhibition of Locomotion via Repolarization of Forces
- Erratum: The first world cell race (Current Biology (2012) 22 (R673-R675))
- Kindlin-1 Regulates Keratinocyte Electrotaxis
- Golgi anti-apoptotic proteins are highly conserved ion channels that affect apoptosis and cell migration
- L-selectin shedding is activated specifically within transmigrating pseudopods of monocytes to regulate cell polarity in vitro
- Epithelial inflammation resulting from an inherited loss-of-function mutation in EGFR
- Mutually exclusive roles of SHARPIN in integrin inactivation and NF-κB signaling
- Direct interactions with the integrin β1 cytoplasmic tail activate the Abl2/Arg kinase
- An open access microfluidic device for the study of the physical limits of cancer cell deformation during migration in confined environments
- Large Intragenic KRT1 Deletion Underlying Atypical Autosomal Dominant Keratinopathic Ichthyosis
- TNFα promotes CAR-dependent migration of leukocytes across epithelial monolayers
- Alternative mechanisms for talin to mediate integrin function
- A direct interaction between fascin and microtubules contributes to adhesion dynamics and cell migration
- 3β1 integrins regulate CD151 complex assembly and membrane dynamics in carcinoma cells within 3D environments
- Fascin Regulates Nuclear Movement and Deformation in Migrating Cells
- Simultaneous FRAP, FLIM and FAIM for measurements of protein mobility and interaction in living cells
- ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis
- Time-resolved multifocal multiphoton microscope for high speed FRET imaging in vivo
- Mutations in GRHL2 Result in an Autosomal-Recessive Ectodermal Dysplasia Syndrome
- Mutations in EXPH5 result in autosomal recessive inherited skin fragility
- Erratum: BPAG1-e restricts keratinocyte migration through control of adhesion stability (Journal of Investigative Dermatology)
- An antagonistic interaction between PlexinB2 and Rnd3 controls RhoA activity and cortical neuron migration
- Disruption of the coxsackievirus and adenovirus receptor-homodimeric interaction triggers lipid microdomain-and dynamin-dependent endocytosis and lysosomal targeting
- ADAM8 as a drug target in pancreatic cancer
- Lamellipodia are crucial for haptotactic sensing and response
- Prostaglandins regulate nuclear localization of Fascin and its function in nucleolar architecture
- In vivo collective cell migration requires an LPAR2-dependent increase in tissue fluidity
- Differential activation of the PI 3-kinase effectors AKT/PKB and p70 S6 kinase by compound 48/80 is mediated by PKCalpha.
- Cell migration
- Erratum: Fascin: A key regulator of cytoskeletal dynamics (International Journal of Biochemistry and Cell Biology (2010) 42: 10 (1614-1617))
- The role of kindlins in cell biology and relevance to human disease
- R-Ras regulates beta(1)-integrin trafficking via effects on membrane ruffling and endocytosis
- Defects in cell spreading and ERK1/2 activation in fibroblasts with lamin A/C mutations.
- Imaging of cell adhesion events in 3D matrix environments.
- A novel Rho-dependent pathway that drives interaction of fascin-1 with p-Lin-11/Isl-1/Mec-3 kinase (LIMK) 1/2 to promote fascin-1/actin binding and filopodia stability.
- Complement fragment C3a controls mutual cell attraction during collective cell migration.
- SHARPIN is an endogenous inhibitor of β1-integrin activation.
- Differential regulation of adhesion complex turnover by ROCK1 and ROCK2.
- Alpha v beta3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration.
- Live cell imaging analysis of receptor function.
- Loss-of-function FERMT1 mutations in kindler syndrome implicate a role for fermitin family homolog-1 in integrin activation.
- In Vitro and in Vivo Characterization of Molecular Interactions between Calmodulin, Ezrin/Radixin/Moesin, and L-selectin.
- Spatial and temporal regulation of integrin signalling during cell migration.
- β1 integrins regulate fibroblast chemotaxis through control of N-WASP stability.
- Proneural transcription factors regulate different steps of cortical neuron migration through Rnd-mediated inhibition of RhoA signaling.
- Imaging cells within 3D cell-derived matrix.
- Dissecting cell adhesion architecture using advanced imaging techniques.
- CAR modulates E-cadherin dynamics in the presence of adenovirus type 5.
- Measuring FRET using time-resolved FLIM.
- Endothelial FAK is required for tumour angiogenesis.
- Podoplanin associates with CD44 to promote directional cell migration.
- Advances in imaging cell-matrix adhesions.
- Fascin: a key regulator of cytoskeletal dynamics.
- Collective chemotaxis requires contact-dependent cell polarity.
- Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics.
- Flexible and stable optical parametric oscillator based laser system for coherent anti-Stokes Raman scattering microscopy.
- Coxsackie adenovirus receptor (CAR) regulates integrin function through activation of p44/42 MAPK.
- PAK4: a pluripotent kinase that regulates prostate cancer cell adhesion.
- Activated ezrin promotes cell migration through recruitment of the GEF Dbl to lipid rafts and preferential downstream activation of Cdc42.
- HS1-associated protein X-1 regulates carcinoma cell migration and invasion via clathrin-mediated endocytosis of integrin alphavbeta6.
- R-Ras regulates beta1-integrin trafficking via effects on membrane ruffling and endocytosis.
- New insights into the dynamics of cell adhesions.
- MyosinV controls PTEN function and neuronal cell size.
- Contact inhibition of locomotion in vivo controls neural crest directional migration.
- Targeting of the F-actin-binding protein drebrin by the microtubule plus-tip protein EB3 is required for neuritogenesis.
- Rac regulates the interaction of fascin with protein kinase C in cell migration.
- Directional migration of neural crest cells in vivo is regulated by Syndecan-4/Rac1 and non-canonical Wnt signaling/RhoA.
- Quantification of integrin receptor agonism by fluorescence lifetime imaging.
- Dual actin-bundling and protein kinase C-binding activities of fascin regulate carcinoma cell migration downstream of Rac and contribute to metastasis.
- Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments.
- Adhesion dynamics: mechanisms and measurements.
- Erratum: MyosinV controls PTEN function and neuronal cell size (Nature Cell Biology (2009) vol.11 (1191-1196))
- Dissecting cell adhesion architecture using advanced imaging techniques.
- Dissecting cell adhesion architecture using advanced imaging techniques
- Preface
- Optical parametric oscillator system for CARS microscopy
- Optical parametric oscillator system for cars microscopy
- Analysis of the interaction between RGD-expressing adenovirus type 5 fiber knob domains and alphavbeta3 integrin reveals distinct binding profiles and intracellular trafficking.
- Spatially distinct binding of Cdc42 to PAK1 and N-WASP in breast carcinoma cells.
- Interaction of fascin and protein kinase Calpha: a novel intersection in cell adhesion and motility.
- Site-directed perturbation of protein kinase C- integrin interaction blocks carcinoma cell chemotaxis.
- A novel PKC-regulated mechanism controls CD44 ezrin association and directional cell motility.
- Intracellular coupling of adhesion receptors: molecular proximity measurements.
- Mechanical load and serum growth factors enhance expression, synthesis and processing of procollagen in human dermal fibroblasts
- Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2
- Integrin-protein kinase C relationships
- Effects of the -1438-A/G serotonin 2A receptor promotor polymorphism on expression
- Remediation of BTEX and trichloroethene: Current knowledge with special emphasis on phytoremediation
- Mechanical load enhances procollagen processing in dermal fibroblasts by regulating levels of procollagen C-proteinase
- Scanning total internal reflection fluorescence imaging
- Ezrin is a downstream effector of trafficking PKC-integrin complexes involved in the control of cell motility
- Imaging protein-protein interactions in cell motility using fluorescence resonance energy transfer (FRET)
- HAX-1 regulates carcinoma cell migration and invasion via clathrin-mediated endocytosis of integrin v6
- Imaging protein-protein interactions in cell motility using FRET
- ERG activity is regulated by endothelial FAK coupling with TRIM25/USP9x in vascular patterning
- Nuclear fascin regulates cancer cell survival
- Epithelial Coxsackievirus Adenovirus Receptor promotes house dust mite-induced lung inflammation
- A method for reproducible high‐resolution imaging of 3D cancer cell spheroids
- Comorbidities of keloid and hypertrophic scars in UK Biobank
- α4/α9 integrins coordinate epithelial cell migration through local suppression of MAP kinase signaling pathways
- Comorbidities of Keloid and Hypertrophic Scars Among Participants in UK Biobank
- SHARPIN is an endogenous inhibitor of beta1-integrin activation
- A novel complement-mediated pathway for human TH2 induction via direct epithelial cell/T cell crosstalk
- The role of Coxsackie and adenoviral receptor in TNF alpha driven inflammation in lung epithelial cells
- The transcription factor Erg regulates expression of HDAC6 and multiple pathways involved in endothelial cell migration and angiogenesis
- Reduced expression of several actin-associated focal adhesion proteins in Kindler syndrome keratinocytes harbouring FERMT1 mutations
- Mutations in the grainyhead-like 2 transcription factor result in a novel autosomal recessive ectodermal dysplasia syndrome
- Establishing the role of BPAG1-e in hemidesmosomal integrity and keratinocyte cell biology
- Potential role of thrombospondin-1 in epidermal atrophy in Kindler syndrome skin
- Reduced tumor load and metastasis in vivo by targeting a metalloprotease-disintegrin, ADAM8, in highly invasive adenocarcinomas
- Germline mutation in EGFR resulting in epithelial inflammation and metabolic abnormalities.
- Proneural factor/Rnd pathways control specific migratory properties of neurons via regulation of RhoA in different subcellular compartments
- Revertant mosaicism in Kindler syndrome resulting from FERMT1 transcriptional gene correction
- Polymorphisms in the dopamine D2 receptor gene: A study of association with schizophrenia in a spanish population isolate
- Normative bladder diary measurements: Night versus day
- Evidence for both inverse agonism at the cannabinoid CB1 receptor and the lack of an endogenous cannabinoid tone in the rat and guinea-pig isolated ileum myenteric plexus-longitudinal muscle preparation
- Genetic indicators of response to olanzapine treatment
- Association of a D2 receptor gene polymorphism with schizophrenia and treatment response in the Basque and Spanish populations
- Clinical applications of pharmacogenetics: Pre-treatment prediction of antipsychotic response
- Gene expression profiling to identify new targets associated with schizophrenia and its treatment
- Reduced expression of basal keratinocyte stem cell markers and altered integrin profiles in Kindler syndrome skin
- Pharmacogenetic prediction of olanzapine response
- Association of a D2 receptor gene polymorphism and schizophrenia in the Spanish population
- Applications of pharmacogenetics and pharmacogenomics in the improvement of psychiatric treatment
- Revertant mosaicism in Kindler syndrome resulting from transcriptional correction of the FERMT1 gene
- Mutations in FERMT1 in Kindler syndrome implicate a role for fermitin family homolog 1 in epidermal stem cell maintenance and integrin activation
- Nondestructive Spatial Lipidomics for Glioma Classification
- Contributions of coxsackievirus adenovirus receptor to tumorigenesis
- L-selectin regulates human neutrophil transendothelial migration
- Loss of RhoE function in dermatofibroma promotes disorganized dermal fibroblast extracellular matrix and increased integrin activation
- Mena regulates nesprin-2 to control actin–nuclear lamina associations, trans-nuclear membrane signalling and gene expression
- The actin-bundling protein Fascin-1 modulates ciliary signalling
- B7-H3 associates with IMPDH2 and regulates cancer cell survival
- The mechanics of bronchoconstriction cause airway epithelial damage and inflammation by excess crowding-induced extrusion
- Bronchoconstriction damages airway epithelia by excess crowding-induced extrusion
- Author Correction
- The RNA binding proteins ZFP36L1 and ZFP36L2 are dysregulated in airway epithelium in human and a murine model of asthma
- Imaging actin organisation and dynamics in 3D
- Bronchoconstriction damages airway epithelia by crowding-induced excess cell extrusion
- Extracellular matrix stiffness activates mechanosensitive signals but limits breast cancer cell spheroid proliferation and invasion
- Data-modeling the interplay between single cell shape, single cell protein expression, and tissue state
- Sequential binding of ezrin and moesin to L-selectin regulates monocyte protrusive behaviour during transendothelial migration
- Integrating Porous Silicon Nanoneedles within Medical Devices for Nucleic Acid Nanoinjection
- Multimodal bioimaging across disciplines and scales: challenges, opportunities and breaking down barriers
- Cell adhesion and migration in disease
- Defining and modeling dynamic spatial heterogeneity within tumor microenvironments