Maddy Parsons

Publications

• Slac2-b Coordinates Extracellular Vesicle Secretion to Regulate Keratinocyte Adhesion and Migration
• Spatial activation of ezrin by epidermal growth factor receptor and focal adhesion kinase co-ordinates epithelial cell migration
• Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth
• Nox4 regulates InsP3 receptor‐dependent Ca2+ release into mitochondria to promote cell survival
• Quantitative real-time imaging of intracellular FRET biosensor dynamics using rapid multi-beam confocal FLIM
• Golgi anti-apoptotic protein: a tale of camels, calcium, channels and cancer
• KIF22 coordinates CAR and EGFR dynamics to promote cancer cell proliferation
• Mena regulates the LINC complex to control actin–nuclear lamina associations, trans-nuclear membrane signalling and cancer gene expression
• Sequential binding of Ezrin and Moesin to L-selectin regulates monocyte protrusive behaviour during transmigration
• New perspectives on integrin-dependent adhesions
• Stimulation of cell invasion by the Golgi Ion Channel GAAP/TMBIM4 via an H2O2-Dependent Mechanism
• L-selectin regulates human neutrophil transendothelial migration.
• Aquaporins differentially regulate cell-cell adhesion in MDCK cells.
• Targeted fluorescence lifetime probes reveal responsive organelle viscosity and membrane fluidity.
• Microfluidic Devices for Examining the Physical Limits of Migration in Confined Environments.
• The manganese(III) porphyrin MnTnHex-2-PyP5+ modulates intracellular ROS and breast cancer cell migration: Impact on doxorubicin-treated cells
• Transmigration of leukocytes across epithelial monolayers
• FMNL2 regulates dynamics of fascin in filopodia
• TNFR1 membrane reorganization promotes distinct modes of TNFα signaling
• Deep sequencing of HIV-1 reverse transcripts reveals the multifaceted antiviral functions of APOBEC3G
• The β3-integrin endothelial adhesome regulates microtubule-dependent cell migration
• Two-Color, Two-Photon Imaging at Long Excitation Wavelengths Using a Diamond Raman Laser
• A small-molecule activator of kinesin-1 drives remodeling of the microtubule network
• NDP52 activates nuclear myosin VI to enhance RNA polymerase II transcription
• CAR: A key regulator of adhesion and inflammation
• Regulation of cell migration by α4 and α9 integrins
• In vivo topology converts competition for cell-matrix adhesion into directional migration
• Imaging of Human Cancer Cells in 3D Collagen Matrices
• Loss of Cannabinoid CB1 Receptors Induces Cortical Migration Malformations and Increases Seizure Susceptibility
• REMBI
• Redistribution of Adhesive Forces through Src/FAK Drives Contact Inhibition of Locomotion in Neural Crest
• A femtosecond Raman generator for long wavelength two-photon and third harmonic generation imaging
• Coagulation Factor XIII-A Subunit Missense Mutation in the Pathobiology of Autosomal Dominant Multiple Dermatofibromas
• Osimertinib and anti-HER3 combination therapy engages immune dependent tumor toxicity via STING activation in trans
• Metabolic perturbations in fibrotic disease
• CAR co-operates with integrins to promote lung cancer cell adhesion and invasion
• Homozygous acceptor splice site mutation in DSG1 disrupts plakoglobin localization and results in keratoderma and skin fragility
• Kindlin-1 regulates epidermal growth factor receptor signalling
• The Na+/H+ exchanger NHE1 localizes as clusters to cryptic lamellipodia and accelerates collective epithelial cell migration
• Fluorescence lifetime imaging for viscosity and diffusion measurements
• α2β1 integrins spatially restrict Cdc42 activity to stabilise adherens junctions
• Live imaging of ERK signalling dynamics in differentiating mouse embryonic stem cells
• Sub-diffraction error mapping for localisation microscopy images
• Dosage-dependent regulation of VAV2 expression by steroidogenic factor-1 drives adrenocortical carcinoma cell invasion
• Control of nuclear organization by F-actin binding proteins
• Local dimensionality determines imaging speed in localization microscopy
• Large Intragenic Deletion in DSTYK Underlies Autosomal-Recessive Complicated Spastic Paraparesis, SPG23
• Tumor angiogenesis is differentially regulated by phosphorylation of endothelial cell focal adhesion kinase tyrosines-397 and -861
• Semidominant GPNMB Mutations in Amyloidosis Cutis Dyschromica
• Fluorescence Recovery After Photobleaching (FRAP) with simultaneous Fluorescence Lifetime and time-resolved Fluorescence Anisotropy Imaging (FLIM & tr-FAIM)
• Using FRET to analyse signals controlling cell adhesion and migration
• PAK4 suppresses PDZ-RhoGEF activity to drive invadopodia maturation in melanoma cells
• Par3 controls neural crest migration by promoting microtubule catastrophe during contact inhibition of locomotion
• CAR regulates epithelial cell junction stability through control of E-cadherin trafficking
• Podoplanin mediates ECM degradation by squamous carcinoma cells through control of invadopodia stability
• Targeted redox inhibition of protein phosphatase 1 by Nox4 regulates eIF2α-mediated stress signaling
• Integrin α3β1-CD151 complex regulates dimerization of ErbB2 via RhoA
• Corrigendum to: Endothelial FAK is required for tumour angiogenesis (EMBO Mol Med, (2010), 2, (516-528), 10.1002/emmm.201000106)
• The light chains of kinesin-1 are autoinhibited
• hGAAP promotes cell adhesion and migration via the stimulation of store-operated Ca2+ entry and calpain 2.
• BPAG1-e Restricts Keratinocyte Migration Through Control of Adhesion Stability.
• Fascin regulates the migration of subventricular zone-derived neuroblasts in the postnatal brain.
• Phosphorylation of the Actin Binding Protein Drebrin at S647 Is Regulated by Neuronal Activity and PTEN.
• FAK-heterozygous mice display enhanced tumour angiogenesis.
• Integrin-Specific Control of Focal Adhesion Kinase and RhoA Regulates Membrane Protrusion and Invasion.
• Stromal Claudin14-heterozygosity, but not deletion, increases tumour blood leakage without affecting tumour growth.
• Germline Mutation in EXPH5 Implicates the Rab27B Effector Protein Slac2-b in Inherited Skin Fragility.
• The first World Cell Race.
• Fascin promotes filopodia formation independent of its role in actin bundling.
• Revertant mosaicism in Kindler syndrome.
• Autosomal recessive epidermolysis bullosa simplex due to loss of BPAG1-e expression.
• The transcription factor Erg regulates expression of histone deacetylase 6 and multiple pathways involved in endothelial cell migration and angiogenesis.
• Kindlin binds migfilin tandem LIM domains and regulates migfilin focal adhesion localization and recruitment dynamics.
• Cadherin Switch during EMT in Neural Crest Cells Leads to Contact Inhibition of Locomotion via Repolarization of Forces
• Erratum: The first world cell race (Current Biology (2012) 22 (R673-R675))
• Kindlin-1 Regulates Keratinocyte Electrotaxis
• Golgi anti-apoptotic proteins are highly conserved ion channels that affect apoptosis and cell migration
• L-selectin shedding is activated specifically within transmigrating pseudopods of monocytes to regulate cell polarity in vitro
• Epithelial inflammation resulting from an inherited loss-of-function mutation in EGFR
• Mutually exclusive roles of SHARPIN in integrin inactivation and NF-κB signaling
• Direct interactions with the integrin β1 cytoplasmic tail activate the Abl2/Arg kinase
• An open access microfluidic device for the study of the physical limits of cancer cell deformation during migration in confined environments
• Large Intragenic KRT1 Deletion Underlying Atypical Autosomal Dominant Keratinopathic Ichthyosis
• TNFα promotes CAR-dependent migration of leukocytes across epithelial monolayers
• Alternative mechanisms for talin to mediate integrin function
• A direct interaction between fascin and microtubules contributes to adhesion dynamics and cell migration
• 3β1 integrins regulate CD151 complex assembly and membrane dynamics in carcinoma cells within 3D environments
• Fascin Regulates Nuclear Movement and Deformation in Migrating Cells
• Simultaneous FRAP, FLIM and FAIM for measurements of protein mobility and interaction in living cells
• ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis
• Time-resolved multifocal multiphoton microscope for high speed FRET imaging in vivo
• Mutations in GRHL2 Result in an Autosomal-Recessive Ectodermal Dysplasia Syndrome
• Mutations in EXPH5 result in autosomal recessive inherited skin fragility
• Erratum: BPAG1-e restricts keratinocyte migration through control of adhesion stability (Journal of Investigative Dermatology)
• An antagonistic interaction between PlexinB2 and Rnd3 controls RhoA activity and cortical neuron migration
• Disruption of the coxsackievirus and adenovirus receptor-homodimeric interaction triggers lipid microdomain-and dynamin-dependent endocytosis and lysosomal targeting
• ADAM8 as a drug target in pancreatic cancer
• Lamellipodia are crucial for haptotactic sensing and response
• Prostaglandins regulate nuclear localization of Fascin and its function in nucleolar architecture
• In vivo collective cell migration requires an LPAR2-dependent increase in tissue fluidity
• Differential activation of the PI 3-kinase effectors AKT/PKB and p70 S6 kinase by compound 48/80 is mediated by PKCalpha.
• Cell migration
• Erratum: Fascin: A key regulator of cytoskeletal dynamics (International Journal of Biochemistry and Cell Biology (2010) 42: 10 (1614-1617))
• The role of kindlins in cell biology and relevance to human disease
• R-Ras regulates beta(1)-integrin trafficking via effects on membrane ruffling and endocytosis
• Defects in cell spreading and ERK1/2 activation in fibroblasts with lamin A/C mutations.
• Imaging of cell adhesion events in 3D matrix environments.
• A novel Rho-dependent pathway that drives interaction of fascin-1 with p-Lin-11/Isl-1/Mec-3 kinase (LIMK) 1/2 to promote fascin-1/actin binding and filopodia stability.
• Complement fragment C3a controls mutual cell attraction during collective cell migration.
• SHARPIN is an endogenous inhibitor of β1-integrin activation.
• Differential regulation of adhesion complex turnover by ROCK1 and ROCK2.
• Alpha v beta3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration.
• Live cell imaging analysis of receptor function.
• Loss-of-function FERMT1 mutations in kindler syndrome implicate a role for fermitin family homolog-1 in integrin activation.
• In Vitro and in Vivo Characterization of Molecular Interactions between Calmodulin, Ezrin/Radixin/Moesin, and L-selectin.
• Spatial and temporal regulation of integrin signalling during cell migration.
• β1 integrins regulate fibroblast chemotaxis through control of N-WASP stability.
• Proneural transcription factors regulate different steps of cortical neuron migration through Rnd-mediated inhibition of RhoA signaling.
• Imaging cells within 3D cell-derived matrix.
• Dissecting cell adhesion architecture using advanced imaging techniques.
• CAR modulates E-cadherin dynamics in the presence of adenovirus type 5.
• Measuring FRET using time-resolved FLIM.
• Endothelial FAK is required for tumour angiogenesis.
• Podoplanin associates with CD44 to promote directional cell migration.
• Advances in imaging cell-matrix adhesions.
• Fascin: a key regulator of cytoskeletal dynamics.
• Collective chemotaxis requires contact-dependent cell polarity.
• Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics.
• Flexible and stable optical parametric oscillator based laser system for coherent anti-Stokes Raman scattering microscopy.
• Coxsackie adenovirus receptor (CAR) regulates integrin function through activation of p44/42 MAPK.
• PAK4: a pluripotent kinase that regulates prostate cancer cell adhesion.
• Activated ezrin promotes cell migration through recruitment of the GEF Dbl to lipid rafts and preferential downstream activation of Cdc42.
• HS1-associated protein X-1 regulates carcinoma cell migration and invasion via clathrin-mediated endocytosis of integrin alphavbeta6.
• R-Ras regulates beta1-integrin trafficking via effects on membrane ruffling and endocytosis.
• New insights into the dynamics of cell adhesions.
• MyosinV controls PTEN function and neuronal cell size.
• Contact inhibition of locomotion in vivo controls neural crest directional migration.
• Targeting of the F-actin-binding protein drebrin by the microtubule plus-tip protein EB3 is required for neuritogenesis.
• Rac regulates the interaction of fascin with protein kinase C in cell migration.
• Directional migration of neural crest cells in vivo is regulated by Syndecan-4/Rac1 and non-canonical Wnt signaling/RhoA.
• Quantification of integrin receptor agonism by fluorescence lifetime imaging.
• Dual actin-bundling and protein kinase C-binding activities of fascin regulate carcinoma cell migration downstream of Rac and contribute to metastasis.
• Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments.
• Adhesion dynamics: mechanisms and measurements.
• Erratum: MyosinV controls PTEN function and neuronal cell size (Nature Cell Biology (2009) vol.11 (1191-1196))
• Dissecting cell adhesion architecture using advanced imaging techniques.
• Dissecting cell adhesion architecture using advanced imaging techniques
• Preface
• Optical parametric oscillator system for CARS microscopy
• Optical parametric oscillator system for cars microscopy
• Analysis of the interaction between RGD-expressing adenovirus type 5 fiber knob domains and alphavbeta3 integrin reveals distinct binding profiles and intracellular trafficking.
• Spatially distinct binding of Cdc42 to PAK1 and N-WASP in breast carcinoma cells.
• Interaction of fascin and protein kinase Calpha: a novel intersection in cell adhesion and motility.
• Site-directed perturbation of protein kinase C- integrin interaction blocks carcinoma cell chemotaxis.
• A novel PKC-regulated mechanism controls CD44 ezrin association and directional cell motility.
• Intracellular coupling of adhesion receptors: molecular proximity measurements.
• Mechanical load and serum growth factors enhance expression, synthesis and processing of procollagen in human dermal fibroblasts
• Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2
• Integrin-protein kinase C relationships
• Effects of the -1438-A/G serotonin 2A receptor promotor polymorphism on expression
• Remediation of BTEX and trichloroethene: Current knowledge with special emphasis on phytoremediation
• Mechanical load enhances procollagen processing in dermal fibroblasts by regulating levels of procollagen C-proteinase
• Scanning total internal reflection fluorescence imaging
• Ezrin is a downstream effector of trafficking PKC-integrin complexes involved in the control of cell motility
• Imaging protein-protein interactions in cell motility using fluorescence resonance energy transfer (FRET)
• HAX-1 regulates carcinoma cell migration and invasion via clathrin-mediated endocytosis of integrin v6
• Imaging protein-protein interactions in cell motility using FRET
• ERG activity is regulated by endothelial FAK coupling with TRIM25/USP9x in vascular patterning
• Nuclear fascin regulates cancer cell survival
• Epithelial Coxsackievirus Adenovirus Receptor promotes house dust mite-induced lung inflammation
• A method for reproducible high‐resolution imaging of 3D cancer cell spheroids
• Comorbidities of keloid and hypertrophic scars in UK Biobank
• α4/α9 integrins coordinate epithelial cell migration through local suppression of MAP kinase signaling pathways
• Comorbidities of Keloid and Hypertrophic Scars Among Participants in UK Biobank
• SHARPIN is an endogenous inhibitor of beta1-integrin activation
• A novel complement-mediated pathway for human TH2 induction via direct epithelial cell/T cell crosstalk
• The role of Coxsackie and adenoviral receptor in TNF alpha driven inflammation in lung epithelial cells
• The transcription factor Erg regulates expression of HDAC6 and multiple pathways involved in endothelial cell migration and angiogenesis
• Reduced expression of several actin-associated focal adhesion proteins in Kindler syndrome keratinocytes harbouring FERMT1 mutations
• Mutations in the grainyhead-like 2 transcription factor result in a novel autosomal recessive ectodermal dysplasia syndrome
• Establishing the role of BPAG1-e in hemidesmosomal integrity and keratinocyte cell biology
• Potential role of thrombospondin-1 in epidermal atrophy in Kindler syndrome skin
• Reduced tumor load and metastasis in vivo by targeting a metalloprotease-disintegrin, ADAM8, in highly invasive adenocarcinomas
• Germline mutation in EGFR resulting in epithelial inflammation and metabolic abnormalities.
• Proneural factor/Rnd pathways control specific migratory properties of neurons via regulation of RhoA in different subcellular compartments
• Revertant mosaicism in Kindler syndrome resulting from FERMT1 transcriptional gene correction
• Polymorphisms in the dopamine D2 receptor gene: A study of association with schizophrenia in a spanish population isolate
• Normative bladder diary measurements: Night versus day
• Evidence for both inverse agonism at the cannabinoid CB1 receptor and the lack of an endogenous cannabinoid tone in the rat and guinea-pig isolated ileum myenteric plexus-longitudinal muscle preparation
• Genetic indicators of response to olanzapine treatment
• Association of a D2 receptor gene polymorphism with schizophrenia and treatment response in the Basque and Spanish populations
• Clinical applications of pharmacogenetics: Pre-treatment prediction of antipsychotic response
• Gene expression profiling to identify new targets associated with schizophrenia and its treatment
• Reduced expression of basal keratinocyte stem cell markers and altered integrin profiles in Kindler syndrome skin
• Pharmacogenetic prediction of olanzapine response
• Association of a D2 receptor gene polymorphism and schizophrenia in the Spanish population
• Applications of pharmacogenetics and pharmacogenomics in the improvement of psychiatric treatment
• Revertant mosaicism in Kindler syndrome resulting from transcriptional correction of the FERMT1 gene
• Mutations in FERMT1 in Kindler syndrome implicate a role for fermitin family homolog 1 in epidermal stem cell maintenance and integrin activation
• Nondestructive Spatial Lipidomics for Glioma Classification
• Contributions of coxsackievirus adenovirus receptor to tumorigenesis
• L-selectin regulates human neutrophil transendothelial migration
• Loss of RhoE function in dermatofibroma promotes disorganized dermal fibroblast extracellular matrix and increased integrin activation
• Mena regulates nesprin-2 to control actin–nuclear lamina associations, trans-nuclear membrane signalling and gene expression
• The actin-bundling protein Fascin-1 modulates ciliary signalling
• B7-H3 associates with IMPDH2 and regulates cancer cell survival
• The mechanics of bronchoconstriction cause airway epithelial damage and inflammation by excess crowding-induced extrusion
• Bronchoconstriction damages airway epithelia by excess crowding-induced extrusion
• Author Correction
• The RNA binding proteins ZFP36L1 and ZFP36L2 are dysregulated in airway epithelium in human and a murine model of asthma
• Imaging actin organisation and dynamics in 3D
• Bronchoconstriction damages airway epithelia by crowding-induced excess cell extrusion