# # Headers for SLEandCOVID19_cross-trait_meta.txt and SLEandCOVID19_cross-trait_inverse_meta.txt
# Chromosome - chromosome
# Position - base pair position based on GRCh37
# MarkerName - rsid
# Allele1 - alternative and effect allele (beta is for this allele)
# Allele2 - reference and non-effect allele
# Freq1 - effect allele frequency in the meta-analysis
# Effect - effect size on log(OR) scale in a cross-trait meta-analysis
# StdErr- standard error of effect size
# P-value - p-value

# SLE effect size is of a meta-analysis of European component of the Immunochip data[1] and three previously published European GWASs (the SLE main cohort [2]; the Genentech cohort[3]; the SLEGEN cohort[4]).
[1] Langefeld, C.D. et al. Transancestral mapping and genetic load in systemic lupus erythematosus. Nat Commun 8, 16021 (2017).
[2] Bentham, J. et al. Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus. Nat Genet 47, 1457-1464 (2015).
[3] Hom, G. et al. Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. N Engl J Med 358, 900-9 (2008).
[4] International Consortium for Systemic Lupus Erythematosus, G. et al. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet 40, 204-10 (2008).

# severe COVID-19 data is from https://www.covid19hg.org/results/r6/, A2_ALL_leave_23andme.

# # Disclaimer: If you choose to download and analyse these data, you acknowledge that:
# # - These data are provided on an “as-is” basis, and no warranty is provided as to their performance or fitness for any purpose
# # - You and your collaborators are in compliance with all applicable local/state/national/international laws or regulations and institutional policies regarding human subjects and genetics research
# # - You will cite Wang Y et al. 2022 in any communications or publications arising directly or indirectly from these data
# # - All data here are released for the benefit of the wider biomedical community for use in the investigation of the genetics of susceptibility to Autoimmune/infectious diseases and wider genetics research.